Potts Hamiltonian models of protein co-variation, free energy landscapes, and evolutionary fitness
نویسندگان
چکیده
منابع مشابه
Potts Hamiltonian models of protein co-variation, free energy landscapes, and evolutionary fitness.
Potts Hamiltonian models of protein sequence co-variation are statistical models constructed from the pair correlations observed in a multiple sequence alignment (MSA) of a protein family. These models are powerful because they capture higher order correlations induced by mutations evolving under constraints and help quantify the connections between protein sequence, structure, and function mai...
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ژورنال
عنوان ژورنال: Current Opinion in Structural Biology
سال: 2017
ISSN: 0959-440X
DOI: 10.1016/j.sbi.2016.11.004